Vinorelbina [Spanish]
Vinorelbina [Spanish] Brand names, Vinorelbina [Spanish] Analogs
Vinorelbina [Spanish] Brand Names Mixture
- No information avaliable
Vinorelbina [Spanish] Chemical_Formula
C45H54N4O8
Vinorelbina [Spanish] RX_link
http://www.rxlist.com/cgi/generic2/vinor.htm
Vinorelbina [Spanish] fda sheet
Vinorelbina [Spanish] msds (material safety sheet)
Vinorelbina [Spanish] Synthesis Reference
No information avaliable
Vinorelbina [Spanish] Molecular Weight
778.932 g/mol
Vinorelbina [Spanish] Melting Point
No information avaliable
Vinorelbina [Spanish] H2O Solubility
No information avaliable
Vinorelbina [Spanish] State
Solid
Vinorelbina [Spanish] LogP
5.829
Vinorelbina [Spanish] Dosage Forms
Solution
Vinorelbina [Spanish] Indication
For the treatment of non-small-cell lung carcinoma
Vinorelbina [Spanish] Pharmacology
Vinorelbine is a vinca alkaloid antineoplastic agent used as a treatment for various cancers including breast cancer, Hodgkin's disease, Kaposi's sarcoma, and testicular cancer. The vinca alkaloids are structurally similar compounds comprised of 2 multiringed units, vindoline and catharanthine. The vinca alkaloids have become clinically useful since the discovery of their antitumour properties in 1959. Initially, extracts of the periwinkle plant (Catharanthus roseus) were investigated because of putative hypoglycemic properties, but were noted to cause marrow suppression in rats and antileukemic effects in vitro. Vinorelbine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. Vinorelbine has some immunosuppressant effect. The vinca alkaloids are considered to be cell cycle phase-specific.
Vinorelbina [Spanish] Absorption
No information avaliable
Vinorelbina [Spanish] side effects and Toxicity
No information avaliable
Vinorelbina [Spanish] Patient Information
No information avaliable
Vinorelbina [Spanish] Organisms Affected
Humans and other mammals
![Vinorelbina_[Spanish]](/images/rx/APRD00101.gif)
